Clinical Sources & Calculation Methodology

Clinical review date: August 12, 2026

Professional reference only. Verify current labeling, the measured patient inputs, units, arithmetic, institutional protocol, scope of practice, and medical direction before clinical use. Linked sources do not endorse this app.

Calculation transparency

On supported Android paths, interactive medication results display the governing formula, entered values with units, explicit mass/time conversions, uncapped result, minimum/maximum application, and rounding before the final displayed value. Native iOS medication references remain static: they do not accept patient weight or other patient-specific medication inputs and do not calculate or display patient-specific dose, volume, or pump-rate results.

Source ledger

Every medication card includes a direct product-label or official product-information link for its representative formulation. Match the exact product, concentration, current labeling, and controlling protocol; a linked label may not cover protocol-directed or off-label transport use.

Adult cardiac arrest and bradycardia

American Heart Association — 2025 Adult Advanced Life Support

Pediatric arrest and defibrillation

American Heart Association — 2025 Pediatric Advanced Life Support

Neonatal resuscitation

American Heart Association — 2025 Neonatal Resuscitation

Sepsis and septic shock

Society of Critical Care Medicine — Surviving Sepsis Campaign 2026

Cardiogenic shock

American College of Cardiology — 2025 Concise Clinical Guidance

Acute pulmonary embolism

AHA/ACC multisociety acute pulmonary embolism guideline, 2026

Intracerebral hemorrhage

AHA/ASA — 2022 Spontaneous ICH Guideline

Aneurysmal subarachnoid hemorrhage

AHA/ASA — 2023 aSAH Guideline summary

Hyperglycemic crises

ADA/EASD/JBDS/AACE/DTS — 2024 Consensus Report

Acute kidney injury definition and staging

KDIGO — Acute Kidney Injury Guideline · KDIGO AKI guideline update status

Hyponatremia and paired urine studies

ESICM/ESE/ERA — Clinical Practice Guideline on Hyponatraemia

Acute hyperkalemia

UK Kidney Association — 2023 Hyperkalaemia Guideline

ARDS oxygenation criteria

Global Definition of Acute Respiratory Distress Syndrome, 2024

Troponin and myocardial injury

Fourth Universal Definition of Myocardial Infarction

Disseminated intravascular coagulation

ISTH SSC — Updated Definition and Scoring of DIC, 2025

Thrombotic microangiopathy and schistocytes

ICSH — 2021 Schistocyte Recommendations · Emergency evaluation of thrombotic microangiopathy

Adult HLH recognition

HiHASC — 2023 Adult HLH Diagnostic Consensus Guideline

Refeeding syndrome

ASPEN — Consensus Recommendations for Refeeding Syndrome

Acute pancreatitis

American College of Gastroenterology — 2024 Acute Pancreatitis Guideline

Severe traumatic brain injury

Brain Trauma Foundation — Severe TBI Guidelines · Prehospital TBI Guidelines, Third Edition

Open pneumothorax

Joint Trauma System — TCCC Guidelines 2026

Anaphylaxis

AAAAI/ACAAI — 2023 Practice Parameter Update

Rapid sequence intubation

Society of Critical Care Medicine — RSI Guideline 2023

Protamine

FDA/DailyMed — Protamine Sulfate injection label

Local protocol: push-dose epinephrine

This is explicitly labeled a local agency protocol, not a universal national regimen: expel 1 mL from a 10 mL 0.9% sodium chloride flush; add 1 mL from epinephrine 1 mg/10 mL (0.1 mg/mL); final volume 10 mL at 10 mcg/mL. Label immediately. The local first dose is 5 mL (50 mcg), with reassessment/repeat only as directed while a titratable infusion is prepared. Pediatric use requires an exact agency protocol or online medical-control order.

Reuse

The app uses short original paraphrases and links. It does not reproduce publisher algorithms, figures, tables, or substantial prose. FDA/U.S. government material may be public domain, but trademarks and third-party material remain protected.

Report source or calculation concerns to CCTCriticalCare@gmail.com.